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that's, stimulation of CD74 with exogenous MIF may cause an too much inflammatory state, as MIF is able to stimulating CXCR2 and CXCR4 receptors in addition to CD74. CXCR2 and CXCR4 receptors when activated promote inflow of neutrophils and lymphocytes, respectively (63, sixty four). In wholesome blood MIF is predominantly expressed by B cells [47